Is it ok.to take .25 mg of lorazepam after an hour or two of white wine?

Not a good plan: Lorazepam, even at low dose, is still a sedating drug like alcohol (in the wine). Combining the 2 is not a good idea. Their effects add together to create more sedation and intoxication than either would create alone.

Not advisable.: Both alcohol and Lorazepam are sedative like substances and their effects are additive, and even enhance one another's effect. You could become much more lethargic and drowsy than you expect from combining the two - even within an hour or two.