What is the best time of the day to take a baby aspirin for heart therapy purposes?

Night: Studies show heart attack occur early in the morning when blood flow slows down - Aspirin also helps with night muscle aches so helps both ways.

With food: Several guidelines recommend early use of single doses of Aspirin in various ranges as prophylaxis against cardiovascular events. The dose of Aspirin varies not only with the indication but also between different guidelines. There is no particular time frame identified, but in general an Aspirin tablet should be taken with a small meal.

Any time.: Aspirin's antiplatelet effect lasts for approximately 8 days; therefore, it does not matter what time of day one takes a daily dose.