What is the main difference between thalassemia and sickle cell anemia?

SICKLE CELL AFFECTS : With sickle cell the spleen can be destroyed by the crisis episodes.

See below.: Sickle cell produces an abnormal hemoglobin that sickles in various circumstances (like fever or cold weather). Bea-thalassemia produces decreased amounts of hemoglobin, causing an abnormal arrangement of hemoglobin within the red cell. Both can have variable disease severity.