Can prolonged use of hydroxychloroquine cause retinopathy?

Yes: Hydroxychloroquine-associated retinopathy is more common based on a higher cumulative dosage. For standard doses, your risk will increase after 5 years of use, but if you are using a higher dose or are petite that will affect the timeline. Your rheumatologist and/or ophthalmologist should be able to give you more guidance.

Yes: Per Drugs.Com: "Uncommon (0.1% to 1%): Retinopathy (with changes in pigmentation and visual field defects)." "Retinopathy is uncommon if the recommended daily dose is not exceeded. It is usually reversible if therapy is discontinued. If allowed to develop, there may be a risk of progression even after treatment withdrawal."