What is the genetics of cleft palate?

CLeft: This happens when the facial bones fail to fuse properly. There are environmental as well as genetic factors. The genetic factors for the more common type are patchy however for the more severe syndrome it is better understood. You should talk to your dentist and md to get a referral to a genetics specialist if you require more info.

Improper fusion: Clefting results from the lack of fusion of bilateral anatomic elements in utero, and these take place during the 8th to 12th week of pregnancy. There are genetic markers that are involved and can be passed down through generations. Environmental factors can be related as well, as during that critical period, smoking, drinking alcohol or certain medications may be involved.

Nonsyndromic cleft: A cleft is termed nonsyndromic (nscl/p) when the affected patient has no other physical problems or any delay in motor or cognitive development. Nscl/p occurs in 26% of case with positive family history. The chance of a sibbling also has the cl/p is 30-40 times the risk in the general population. Exam lower lip of the affected patient and parents and if lip pit found, recurrence risk increases.