Why do people with sickle cell anemia suffer from leg ulcers?

Blood flow and oxyge: Sickle cells both slow blood flow and decrease oxygen carrying capacity of blood leading to ulcers. Try nitro paste near not on ulcer.

Compression tx: Add compression therapy to the regimen to decrease the swelling and increase the wound healing.

Poor circulation: That is due to poor perfusion and circulation to the legs-due to vaso-occlusive complication from the sickle cell disease. The risk is higher in those who have lower hematocrit level and in those with more hemolysis. Hydroxyurea which is a drug used in sickle cell anemia also can cause leg ulcer.

Complicated: Probably the best explanation is that they develop a shunting of blood from the veins to the arteries this bypasses some areas and causes them to be deprived of nutrients this causes the tissue to die producing an ulcer.