Could smoking weed worsen my leg claudication?

Yes: Yes, even smoking of marijuana has been shown to have adverse effects on blood vessels. There are debates about this, but the official stance by the society of vascular surgery is that it does adversely affect blood vessels.

Yes: Nicotine in tobacco smoking damages the lining of blood vessels, some one with claudication pains has already damaged blood vessels due to atheromatous deposits , smoking is going to make it worse.So don't smoke.

Yes: Smoking anything will displace oxygen molecules with carbon monoxide molecules. While that's not a problem if your circulation is normal, it's a serious factor for someone with claudication.