A member asked:

Is it normal to lose weight after taking symbyax (fluoxetine and olanzapine) for eight years?

5 doctors weighed in across 2 answers
Dr. Alan Ali answered

Specializes in Psychiatry

Symbiax: Combination of prozac/zyprexa in short run can cause weight gain, depending on the dose. However, I have several patients on the medication for several months that told me they have maintained their wt. Or lost some, when their moods have been stable for some time, while they maintain healthy life-style changes.

Answered 5/7/2016

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Maybe: This drug combination has been implicated in weight gain in about 14% of those using it, but a smaller percentage have experienced weight loss. If this has been a slowly progressive loss over time it may be ok, but if more recent and rapid you probably should be thoroughly reevaluated by your primary care doctor. Good luck and wish you well.

Answered 10/4/2016

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