What could substitute for plaquenil (hydroxychloroquine)?

For what treatment?: Plaquenil (hydroxychloroquine) or Hydroxychloroquine is used to treat multiple different conditions. What would be appropriate to substitute would depend on how it is being used to treat your disease.

See details: It depends why you are taking Plaquenil in the first place. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Why do you feel you need to stop the Plaquenil? Please provide more detailed information if you want a more specific answer.

Nothing safer: Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. So other meds like Imuran and CellCept (mycophenolate mofetil) also reduce flares, but also increases infection.