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A 44-year-old member asked:

Is diphenhydramine hydrochloride and doxylamine succinate ok together?

2 doctor answers4 doctors weighed in
Dr. James Henning
Anesthesiology 50 years experience
Caution Required: Both drugs have similar "mechanisms of action." therefore, the effects they produce are "additive" and, in theory, can pile up to create more effects than would be predicted if each drug were taken by itself...Almost as if 1+1=3! both drugs produce sedation and have anti-histamine properties. So, excessive sleepiness or agitation can happen. Be cautious..Speak to your provider or pharmacist!
Dr. Julian Goldman
Anesthesiology 36 years experience
Not a good idea: Both drugs are antihistamines that depress the central nervous system. Consequently they are often used as sleep aids. Although these are very safe drugs, they have similar effects on the body so taking both may be like taking twice the dose of one. Overdosage can produce side effects that range from minor (dry mouth, excessive sleepiness) to serious (high blood pressure, nausea) to death.

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Similar questions

A 35-year-old member asked:

What is difference between diphenhydramine hydrochloride and doxylamine?

1 doctor answer1 doctor weighed in
Dr. Susumu Inoue
Pediatric Hematology and Oncology 54 years experience
Very similar: Both have anti-allergy property and sedative property. Doxylamine seems to be marketed more for its sedative, or sleep medicine effects, while diphenylhydramine seems to be marketed for more anti-histamin effect.

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Last updated Sep 10, 2019

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