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A member asked:
Why signs of splenomegaly and cardiomegaly in cases of sickle cell disease?
A doctor has provided 1 answer
Sickled RBC's: The spleen not only helps in processing antigens to help wbc's fight infection, it also acts as a "stress test" for rbc's, weeding out the weaker and older ones for recycling. As rbc's "sickle", they cause clumps in the vessels, this is what causes the pain in the joints/chest and also what causes the spleen to swell. If happens in the coronary arteries, can weaken the heart and enlarge it.
Answered 8/10/2015
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