Have osteonecrotic patients reported any symptoms early on in their treatment with bisphosphonates that indicated they would develop osteonecrosis?

Unexplained jaw pain: High dose intravenous biphosphonates are most likely to be associated with osteonecrosis of the jaw. Unexplained jaw pain is often a harbinger of later osteonecrosis.

Pain: Osteonecrosis of the jaw is very rare in bisphosphonate users with an estimated frequency of 3 cases per 10, 000 users. It is most often associated with significant dental work, meaning extractions or implants. The key symptoms is jaw pain.