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A member asked:
How many mg of diphenhydramine is equal to a 10 mg ambien (zolpidem)?
A doctor has provided 1 answer
Not equivalent: Diphenhydramine is an antihistamine that causes drowsiness by blocking histamine receptors. Usual doses are 25-50 mg. Ambien (zolpidem) is what is called a non benzodiazepine hypnotic, it cause drowsiness by binding to the Alpha subunit of the benzodiazepine receptor. Usual dosing is 5-10 mg. As their mechanism of action is completely different, there is no dose equivalency.
Answered 9/22/2019
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