A member asked:

Psych d/c 120 mg prozac and is starting me on 40 mg lexapro (escitalopram) for mdd. are the high doses safe? what about serotonin syndrome?

8 doctors weighed in across 2 answers

Both simultaneously?: Serotonin syndrome is possible, especially at higher doses of any ssri. Treatment failures to ssris are unfortunately not rare. Combination therapies may work better than monotherapy. Ask your psychiatrist about other treatment options if new regimen doesn't work.

Answered 5/8/2016

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Dr. Alan Ali answered

Specializes in Psychiatry

Prozac (fluoxetine): Not sure how long u have been on prozac, (fluoxetine) but since half life of Prozac (fluoxetine) is long, it is best to introduce the other ssri cautiously. Discuss with your doctor.

Answered 5/8/2016

5.6k views

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