Depends on type/form: For example, infantile metachromatic leukodystrophy onset is by age 2, with 50-60% morbidity by 5. Juvenile onset between age 4-10 (20-30% of cases) has slower progression. There are 2 adult-onset forms, one starts with neurologic/motor problems, the other with behavioral challenges. Please ask the attending specialist.
Answered 10/3/2016
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