Why do my eyes feel tired after i take out my contacts?

Dry eyes: Contact lenses are essentially sponges that retain a certain level of moisture by pulling it from the surface of the eye. Dry eyes can result from long-term contact lens wear. Whenever the contacts are removed, the eye has no barrier protecting it from the air, which causes them to feel "tired".

Typically dryness: There could be several causes for your symptoms but dry eye syndrome is yhe most likely.