Can megestrol acetate (20 mg prescription) help to restore missed menstrual cycles?

No: Megace (megestrol) is a very strong progestin that is typically used to treat women with pre-cancerous changes of the uterine lining if they can't or don't want to have a hysterectomy. It helps to thin the lining, but won't restore normal menstrual cycles other progestins can be utilized in some women who skip menses for mos, to 'jump start' or trigger them to bleed after taking them for 10 days every so ofte.