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A member asked:
What is the function of the extra domain in ige & igm?
A doctor has provided 1 answer
Trick question: Are you studying immunology? The extra domain on ige indicates a unique role for the C2 domain in the interaction between ige and fcri. C2 reduces the off-rate of the ige/fcri, thereby resulting in a more stable complex. It is felt that the domain on igm co-contributes to the pentamic structure production.
Answered 2/13/2015
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Recurrent sinus, respiratory, UTI infections.Igm high at 392 mg/dl & IgE high at 222 ku/l. No pneumococcal titers without vaccine. Any idea of cause?
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