A 36-year-old member asked:
What is the function of the extra domain in ige & igm?
1 doctor answer • 1 doctor weighed in
Internal Medicine 57 years experience
Trick question: Are you studying immunology? The extra domain on ige indicates a unique role for the C2 domain in the interaction between ige and fcri. C2 reduces the off-rate of the ige/fcri, thereby resulting in a more stable complex. It is felt that the domain on igm co-contributes to the pentamic structure production.
5.5k viewsAnswered >2 years ago
Last updated Feb 13, 2015
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