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A 36-year-old member asked:

What is the function of the extra domain in ige & igm?

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Dr. Stevan Cordas
Internal Medicine 57 years experience
Trick question: Are you studying immunology? The extra domain on ige indicates a unique role for the C2 domain in the interaction between ige and fcri. C2 reduces the off-rate of the ige/fcri, thereby resulting in a more stable complex. It is felt that the domain on igm co-contributes to the pentamic structure production.

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Last updated Feb 13, 2015

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