Should i feel tired 2 days after colon colonoscopy?

Possibly: The prep can take a lot out of you (pun intended) so a few daqys of rest should be in order.

You might.: If your colonoscopy was performed under sedation, some people occasionally feel a "hangover" effect a day later. However, this is unusual, and would more likely be related to lack of sleep from taking your bowel prep. Propofol anesthesia is very short-acting, and would not be an issue.