My wife and i have finished 2 cycles of clomid without success. can the 3rd cycle of clomid be successful if the other 2 rounds didn't work? i'm losing hope fast as we have unexplained infertility, which makes this situation worse.

Yes it can: Infertility can be very frustrating. Many times patients need a few rounds of Clomid (clomiphene) at increased doses to trigger ovulation and achieve success. Some doctors will add steroids to help it be more effective. Others will need to add intrauterine insemination or a bhcg injection to the clomid (clomiphene). Work with an experienced obgyn or reproductive endocrinologist to help guide you through the process.

1st 3-4 cycles best: Most pregnancies with Clomid (clomiphene) occur in the first 3 to 4 cycles. Clomid (clomiphene) + intrauterine inseminations (iui) can work better than timed intercourse as Clomid (clomiphene) may thicken the cervical mucus. Ultrasound monitoring detects women who get a thin endometrial lining with clomid (clomiphene). If your wife is your age do 3 cycles then see a rei specialist for 'explanation'. Do 1-2 IUI with round 3 if your dr offers it.