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A 28-year-old male asked:

A serotonin inblalance from occasinal drug use mdma, cocaine, marijuana......how long would it take to get it back on track/ with therapy/ meds? about

1 doctor answer6 doctors weighed in
Dr. Seth Kunen
Clinical Psychology 46 years experience
Complicated cocktail: Mdma is a reuptake inhibitor of serotonin, Dopamine (da) & norepinephrine. Long-term use can damage the serotonin system. Cocaine blocks dat (da transporter), inhibits MAO (making amine transmitters more available) & down-regulates da receptors. Thc via cb1 receptors influences hippocampus & can interfere w/ memory. Depending on use patterns, may take up to a year to recover. See comment.
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Dr. Seth Kunen
Dr. Seth Kunen commented
Clinical Psychology 46 years experience
Provided original answer
see http://science.education.nih.gov/supplements/nih2/addiction/guide/lesson4-1.htm for interesting pictures of how MDMA creates damage to cerebral cortex.
Sep 18, 2012
Last updated Jul 20, 2017


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