Complicated cocktail: Mdma is a reuptake inhibitor of serotonin, Dopamine (da) & norepinephrine. Long-term use can damage the serotonin system. Cocaine blocks dat (da transporter), inhibits MAO (making amine transmitters more available) & down-regulates da receptors. Thc via cb1 receptors influences hippocampus & can interfere w/ memory. Depending on use patterns, may take up to a year to recover. See comment.
Answered 7/20/2017
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