Which is better to add with sudefed for uri? benydryl or claritan?

Depends on effect: Benedryl is a great antihistamine & acts quickly. It will tend to dry secretions some but has the problem of lasting only a few hours & entering the brain & making most people drousy. Claritin (loratadine) takes a day or two to kick in but lasts all day & rarely makes anyone drousy. Allegra is similar but may work a little faster. You may need to try both to see if the effect is what you need.

Neither: Benadryl (diphenhydramine) and claratin are antihistamines, more useful for treating allergies than a uri. Benadryl (diphenhydramine) is sometimes added to combination cold medicines, mainly to help you sleep, .