Are there long-term effects of wellbutrin (bupropion)?

Very safe.: Wellbutrin (bupropion) carries no warnings or cautions regarding long term use. Some may monitor kidney function in the elderly. There are cautions regarding seizure risk with initiation or titration of treatment, but this is unlikely unless there is an underlying seizure disorder.

Officially, none: No warnings about long-term use of wellbutrin (bupropion) have been issued. But, you have to realize that its makeup is similar to amphetamine, and is dopamine-enhancing. It can cause jitteriness, twitching, and seizures even in short-term. It can be difficult to wean from, because of irritability and anger -- not unlike nicotine withdrawal for which it is used (as zyban). Ongoing need should be reviewed.