A member asked:
Can anyone explain what a1298c homozygous genetic mutation could cause?
4 doctors weighed in across 2 answers
MTHFR mutation: The genetic finding can possibly increase clotting problems. The mthfr protein is responsible for metabolism of homocysteine. High homocysteine levels can aggravate vessel walls causing a higher risk of clotting. The high homocysteine levels can be treated with folate (folic acid) supplementation, which should decrease the risk.
Answered 6/19/2015
5.6k views
See below: Mthfr 1298 is not associated with higher homocysteine. That is what the 677 does. 1298 can have: • increased ammonia level • decreased Dopamine & serotonin • decreased epi and norepi • decreased nitric oxide • increased blood pressure • muscle tenderness • prone to bh4 shortage. • may benefit from lower protein diet as ammonia depletes bh4.
Answered 6/17/2018
5.3k views
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