What is the relationship of hepatosplenic t-cell lymphoma and low lymphocyte levels in the blood?

Retained in spleen: The spleen can be quite large and contain really high numbers of malignant lymphocytes. In these cases, both normal and malignant lymphocytes can be low in the peripheral blood.

Several options: By itself this question is hard to answer. Low lymphocytes does not mean lymphoma per se, but if there is lymphoma that has been confirmed, then a low white blood count can be due to treatment effects or the state of the lymphoma itself.