What is the best treatment for genital herpes?

Anti-herpes drugs: Acyclovir, famciclovir, or valacyclovir. Of the three, valacyclovir is the most convenient because of its dosing schedule. If herpes outbreaks occur frequently, it's better to use daily suppression with the same medications rather than treating each episode.

Valtrex (valacyclovir) or famvir: Valtrex (valacyclovir) and Famvir are 2 antibiotics that can treat herpes.

It depends...: ...on initial infection or recurrent outbreaks, treatment goals, and other factors. For longstanding infection, valacyclovir or acyclovir by mouth are effective in reducing frequency and severity of outbreaks. Valacyclovir reduces risk of sexual transmission to partners; acyclovir hasn't been studied. Topic treatment (creams, ointments) don't work well. Nothing else works (see comment to follow).