What causes an inhomogeneous spleen in hodgkin lymphoma?

A radiology term: The normal spleen looks quite smooth on ct scans. If it is involved with disease such as with hodgkin or non-hodgkin lymphoma, it's appearance looks different on ct scan or pet/ct: no longer smooth and even but rather has different shades. This is an inhomogeneous appearance as opposed to a homogeneous one.

Lymphoma vs. other: The spleen in hl may be heterogeneous/inhomogeneous/non-uniform due to lymphoma involvement, spleen infarction (death) due to cancer death in the spleen, or infection, or "other". The radiologist may or may not be able to determine that and your oncologist might be able to say more about it with knowing the clinical history.