Subtle disease: It's caused by inactivation, by autoantibody or exacerbation of a birth defect, of the protein that clear activated von willebrand's factor. Little blood clots interfere with kidney and brain function, there is a fever, and unless the plasma is replaced repeatedly (the mainstay of treatment), it is fatal. Thrombotic thrombocytopenic purpura.
Answered 10/4/2016
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