Is it possible for d-amphetamine xr 25 mg make you lose weight?

Yes: It is a stimulant that decreases appetite.

Yes: Amphetamines have a potential side effect of appetite suppression. Before taking it you should check with your doctor to be sure you do not have a health contraindication to using it. It is only a temporary measure. A better approach is proper diet, portion control and exercise, which can give long term positive results.