What's the quickest way to get rid of a blocked nose?

Oxymetazoline: Otc nose sprays containing oxymetazoline or neosynephrine (phenylephrine) are great at decongesting your nose in a hurry, without a lot of side effects in the short term. It can dry and irritate your nose after a few days. If used longer than 3 to 5 days it can have a rebound effect, where your nasal lining swells more than it was in the first place. So only use for 3 to five days.