Lots of things: A low WBC can be from neutritional deficiency, autoimmune diseases, hormone disorders, bone marrow failure states (aplastic anemia, myelodysplastic syndrome) and leukemias. It can also be seen in someone who otherwise seems healthy, and may even have a normal bone marrow on biopsy (benign neutropenia). Viral infections can cause low WBC counts too.
Answered 3/16/2017
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