Can pancreatic cancer be cured with radiation?

Maybe - adjuvant: Pancreas cancer is basically divided into 1) resectable (by surgery) 2) borderline resectable 3) metastatic (spread distantly). Radiation may be used after surgical resection as adjuvant therapy to help local control to prevent relapse. Radiation may also be used alone or with chemo to "downstage" or shrink the tumor to allow surgery. In general, radiation therapy by itself it likely not curative.

Not likely: Radiation serves primarily as an adjunctive treatment, offered in order to improve local control. There are very few "complete responses" when we resect tumors after radiation. In the adjuvant setting (after resection) the benefit of radiation is still under debate. There is an rtog trial open now to help answer this. Surgical resection, when possible, still offers the only real chance of cure.