Is liver affected by glucosamine?

Doubt it: There is not much evidence of liver damage by glucosamine. According to mayo clinic : one patient developed liver inflammation (acute cholestatic hepatitis) after taking glucosamine forte. Review this good article. http://www.mayoclinic.com/health/glucosamine/ns_patient-glucosamine/dsection=safety.

It can be: It is taken up by the liver, where it is metabolized (though the kidneys help excrete it out in the urine as well).