What is the best way to treat poison ivy?

OTC Hydrocortisone: First, ensure that your items of clothing that could have come into contact with the poison ivy are washed well to avoid re-exposure. Try over the counter Hydrocortisone and calamine lotion. Also Benadryl (diphenhydramine) can be helpful. If this doesn't work, your doctor can rx you stronger topicals or even oral Prednisone if it is severe.

Hydrocortisone cream: As long as your rash is somewhat limited in size and doesn't significantly involve the face, Hydrocortisone cream is a good option. If the rash is extensive and/ or involves the face your doctor may need to prescribe an oral steroid pill like prednisone.