Does orlistat cause skin irritation?

Not to my knowlege: I do not know of a skin problem with orlistat. It only makes you poop oil if you have fatty intake and take this drug. If you have a rash and are on orlistat, stop the orlistat and see your pcp.

Drug rash: Almost any medication or supplement you take can cause a rash. The question here is whether the irritation you are having is actually caused by the orlistat. Best to see a dermatologist for this answer because it can be complicated to sort through all the possibilities without seeing a doctor who is very familiar with rashes.