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A member asked:
What does hyper- and hyponatremia do to resting membrane potential of cardiac muscle?
A doctor has provided 1 answer
Depends on K+...: Resting membrane potential is generated in phase 4, by k+ (potassium) ions. Na+ (sodium) channels are only active during phase 0 and are regulated by m, h and j gates. Because phase 4 is mainly controlled by k+ ions, the only way low or high na+ would affect this is in "ion homeostasis" (ih), via the n+/k+ pump. So if na+ was extremely high or low, and affected k+, it could potentially change it.
Answered 9/28/2017
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