Why does a decrease in glutamate rduce abnormal movements in parkinson's?

Decrease stim: Glutamate is a nerve receptor that can cause neuroexcititory and neruodegenerative disease. If glutamate release can be controlled, then some of the movements associated with Parkinson's can be reduced. Drugs that decrease glutamate release are being use in the early, mild form of parkinson's.

Works in animals: Dopamine, an important neurotransmitter, is depleted in the basal ganglia of the brain in parkinson's disease. As a result, the glutaminergic neurons that go from the subthalamic nuclei to the basal ganglia become overactive. Glutamate is an excitatory neurotransmitter. In animal models, blockade of glutamate receptors ameliorates the motor manifestations of pd.