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A 34-year-old member asked:

Could hydrea (hydroxyurea) possibly help children with sickle cell disease?

2 doctor answers8 doctors weighed in
Dr. Ritesh Rathore
Hematology and Oncology 30 years experience
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications.
Dr. Noah Federman
Pediatric Hematology and Oncology 19 years experience
Yes: Hydroxyurea, hydrea, (hydroxyurea) is well known in several large multi-institutional national studies to help children that have sickle cell disease. Particularly in children that have had prior sickle cell crises, Hydroxyurea appears to have benefits in reducing the frequency and severity of sickle cell crises.

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A 21-year-old member asked:

Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

3 doctor answers6 doctors weighed in
Dr. Paul Harper
General Surgery 52 years experience
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells.

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Last updated Jun 25, 2014
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