A member asked:

Is hemochromatosis considered dominant or considered recessive?

2 doctors weighed in across 2 answers
Dr. Jason Hemming answered

Specializes in Gastroenterology

Recessive (sort of): The common genetic defect in the hfe gene for phenotypic hemochromatosis is the c282y/c282y homozygous. However other defects other than c282y can lead to hemochromatosis. C282y heterozgyotes with hhc are though to posses another unclassified defect.

Answered 4/12/2020

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Artificial terms: For the common hemochromatosis gene, two doses (as for a recessive trait) makes it very likely that you'll get seriously sick from it, while one dose does put you at substantial extra risk if you overdo iron intake. As with sickle cell, cystic fibrosis, and many other common "recessive" diseases, some heterozygotes have some resulting health plusses and minuses. I hope this helps.

Answered 6/5/2018

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