Is it painful to give bone marrow?

It can be: If bone marrow is collected the standard way by retrieving it directly from a bone, it can be painful due to pressure when the needle is inserted into the bone. If the cells are collected from the blood, it can be mildly painful after you get the medication to mobilize the marrow cells from within the bone to the blood circulation. The method used depends on the situation at hand.

Mild to moderate : It may be mildly to moderately painful to donate marrow depending on the method used, depth needed to penetrate into the marrow, pain tolerance, other medical conditions, and anxiety.