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A 38-year-old member asked:

Why is it that alpha and beta -thalassemias result in more clinically severe diseases than other types of thalassemia?

2 doctor answers3 doctors weighed in
Dr. Robert Kwok
Pediatrics 33 years experience
Used for blood cells: Alpha globulin (made by the Alpha genes) and beta globulin (made by the beta genes) are the 2 globulin molecules needed to make normal adult hemoglobin (the red stuff in normal red blood cells). Mutations that prevent Alpha and beta globulin production will cause severe symptoms, but other mutations may not be as noticeable if the proteins the other genes make are not as crucial to life.
Dr. Hasan Noubani
Pediatric Cardiology 36 years experience
Anemia: These causes severe anemia with hemodynamic instability . The reason for these are genetic abnormality of the hemoglobin.

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Last updated Jul 20, 2016

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