A 59-year-old member asked:
is alpha thalassemia trait the same thing as alpha thalassemia?
1 doctor answer
Dr. Robert Kwok answered
32 years experience Pediatrics
Not quite: Normal people have 4 Alpha globulin genes. Mutations in 1, 2, 3, or all 4 of the genes cause the 4 levels of Alpha thalassemia. One mutation = silent carrier (no symptoms), 2 mutat. = Alpha trait (mild anemia), 3 mutat. = HGB h disease (anemia sometimes needing transfusions), 4 mutat. = bart's disease (fatal before birth in almost all cases; lifelong transfusions needed to survive if born alive).
Answered on Jun 24, 2014
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