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A member asked:
How quickly does benadryl (diphenhydramine) start to work?
3 doctors weighed in across 2 answers
About 30 minutes: Lasts in the body for about 4-6 hours and then it needs to be redosed.
Answered 7/6/2019
6.3k views
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Benadryl (diphenhydramine): Onset of action is usually between 20-60 minutes.
Answered 7/6/2019
5.5k views
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