Can men with sickle cell disease have healthy children?

Yes: The children are likely to be healthy as long as the children's mother doesn't have sickle cell trait, some other abnormal hemoglobin trait or a thalassemia. An expectant couple with one partner with sickle cell anemia should see a genetic counselor and have the partner tested for hemoglobinopathies and thallasemias prior to conception.

Yes.: Sickle cell disease must be inherited from both parents. So it depends on the mother of the child. If she has sickle cell - all of your children will have sickle cell. If she has sickle cell trait - there is a 50% chance your children will have sickle cell disease, and a 50% chance of your children having sickle cell trait. If she has no sickle cell - your children will have sickle cell trait.