A member asked:

Can midodrine cause a stroke if you take midodrine before bed at nite?

A doctor has provided 1 answer
Dr. Mark Rasak answered

Specializes in Cardiology

Unlikely but possibl: When pts have the indication, midodrine can raise BP by increase vessel tone. At night while lying down BP goes up due to increase return. Midodrine can further increase the BP if given too close to bed and in susceptible pts, can cause a spike in BP and cause a stroke.

Answered 6/10/2014

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Would it hurt a person to take 40mgs of midodrine at 1 time?

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