Can you explain the physiology of neonatal sepsis?

Not in 400 Letters: Essentially, sepsis is a response to a bacterial infection that spreads to the blood stream, and thus the whole body. In neonatal sepsis, a bacterium is transmitted to the newborn at or around the time of birth, and because of an immature immune system, it spreads to affect all organ systems. It can cause significant damage to the organs because of decreased blood pressure and inflammation.