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A 47-year-old member asked:

does endometriosis run in families?

2 doctor answers5 doctors weighed in
Dr. Alfredo Nieves
Gynecology 40 years experience
Endo: No specific gene or genetic pattern have been identified but we defitely see endo in families nonetheless.
Dr. Robert Albee
A Verified Doctor commented
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Women with a first degree relative are 7x more likely to develop endometriosis themselves. Animal studies have long demonstrated that common molecular genetic pathways, specifically K-RAS/MAPK and PTEN/PI13, are involved in the pathogenesis of endometriosis (and endometrioid ovarian carcinoma). Separate studies have identified upregulation of multiple genes within the RAS/RAF/MAPK and P13K patheways in endometriosis patients, as compared to controls. Of note, PTEN and K-RAS mutations were found to play a role in the development of low-grade ovarian endometrioid carcinomas; synchronous mutations were also identified in uterine and ovarian endometrioid carcinomas associated specifically with endometriosis. Moreover, loss of the PTEN tumor suppressor gene has been implicated in progression from endometriosis to endometrioid ovarian cancer. [Giudice, Linda, Johannes Leonardus Henricus Evers, and D. L. Healy. Endometriosis: Science and Practice. Chichester, West Sussex: Wiley-Blackwell, 2012. Print]. Even more recently, Australian researchers conducted a study of 5640 Australian, Japanese and European women with endometriosis and identified four new gene regions linked to the condition.
Nov 13, 2012
Dr. Malcolm Mackenzie
Gynecology 27 years experience
Absolutely: Very often however, older women will have not gotten a diagnosis of endometriosis but will have a long history of pain or hard periods and their daughters will have the same, starting in their early teens and everyone will just think that "its just what women in our family have as their periods" and no one will consider endometriosis.

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Is it safe to run after delivery?

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Yes: After an uncomplicated vaginal delivery it is safe to resume exercising within a few weeks. Each patient should discuss their unique situation with their doctor.
A member asked:

Do sensitivities to vaccinations run in families?

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Dr. Marc Grella
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No: Although anyone can have a reaction to a vaccine, there does not seem to be a higher chance of serious reactions in relatives of those who had serious reactions themselves. Common vaccine reactions: pain (for almost all), fever (in some), swelling of the vaccination area (in a few) and swelling of the entire limb injected (very few). All these reactions vary depending on age and type of vaccine.
A 21-year-old member asked:

I have been hearing a lot about ovarian involvement in endometriosis. What about the tubes?

2 doctor answers2 doctors weighed in
Dr. Alfredo Nieves
Gynecology 40 years experience
Endo: The tubes can also be involved with endometriosis and cause tubal obstruction.
A 26-year-old member asked:

In infertile patients with endometriosis, what is causing the infertility?

2 doctor answers4 doctors weighed in
Dr. Michael Traub
Fertility Medicine 19 years experience
Multiple Factors: Endometriosis can cause scarring of the tubes or even blockage, inflammation of the uterus and ovaries, can affect the egg production of the ovaries, and can affect the uterine lining. Sometimes one source can be easily seen (usually the tubes, even fertilization and egg quality during ivf) but often times the exact cause in an individual can not be detected.
A 20-year-old member asked:

Can you explain why patients with endometriosis have adhesions?

2 doctor answers7 doctors weighed in
Dr. Michael Traub
Fertility Medicine 19 years experience
Sticky Surface: Endometriosis can spread to various surfaces around the pelvic organs. The colon, bladder, uterus, ovaries and tubes move around normally and as they move they touch other things and endometriosis can stick. Endometriosis can also potentially be carried by blood vessels to nearby area, or the surface of the bladder and colon may actually transform itself into endometriosis by chemical signals.

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Last updated May 25, 2017

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