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A 42-year-old member asked:

What are the chances of inheriting cystic fibrosis if one parent has trait?

3 doctor answers6 doctors weighed in
Dr. David Escobar
Dr. David Escobaranswered
Family Medicine 10 years experience
Zero: In order for any possibility of a child acquiring cystic fibrosis (cf), both biological parents would have to have the CF trait as carriers. CF is known as an autosomal recessive disease, which means both parents have to be carriers in order for their child to possibly acquire the disease. In these cases, when both parents are carriers, there is a 25% chance the child will acquire cf.
Dr. William Walsh
Addiction Medicine 18 years experience
Close to zero: CF is autosomal recessive, you need to inherit a defective copy of the gene from each parent. Baring spontaneous mutation or some similarly rare event, both parents need to have the gene to inherit the disease.
Dr. James Ferguson
Pediatrics 47 years experience
Depends: This depends on the profile of the other parent. Their are dozens of mutations that can lead to CF, although most are the delta 509. Both parents must carry a CF related gene for an offspring to get it, and if so the risk is 25%. Carrier testing is available through specialty labs.If only one has trait ,zero.

Similar questions

A 39-year-old member asked:

What are the chances of inheriting cystic fibrosis if one's parent has the trait?

2 doctor answers5 doctors weighed in
Dr. David Escobar
Dr. David Escobaranswered
Family Medicine 10 years experience
Depends on Both: This depends on whether both parents carry the trait. If only one parent is a carrier of the gene, then there is no chance of inheriting cystic fibrosis. However, if both parents carry the CF gene, then there is a 25% chance their child will inherit cystic fibrosis.

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Last updated Oct 1, 2015

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