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A 36-year-old member asked:

Is it possible for one child to have cystic fibrosis while another, from the same parents, be completely normal?

2 doctor answers8 doctors weighed in
Dr. Anthony LaBarbera
Dr. Anthony LaBarberaanswered
Pediatrics 28 years experience
Yes: The child would need to inherit an abnormal gene from both parents. So, the chance of the child having CF is 25%.
Dr. James Ferguson
Pediatrics 46 years experience
Yes: The unaffected carrier parents of a CF kid can produce 3 possible genetic combinations in their kids. CF with 2 abnormal genes(one from each).A normal kid with normal genes (one from each parent). An unaffected carrier (one abnormal and one normal gene). There is risk of CF with any conception, but any combination is possible.

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Last updated Jun 10, 2014
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