Can compression stockings help alleviate tired legs and feet on a long flight?

SURE!: But so can getting up and walking around the cabin when safe, and while sitting contracting your calf muscles and stretching your legs every 30-60 mins.

Can help anytime: Compression stockings can help alleviate tired legs and feet any time, whether you are on a long flight or not. As dr. Villaplana said though, getting up and walking around and stretching while on the plane certainly helps too.